Radiological–Pathological Correlation in Animal Models This review focuses on radiological–pathological correlation of Mycoplasma pneumonia in mice and humans, and the changes of pulmonary involvement patterns reflecting by host cell-mediated immunity (CMI) levels. However, there has been little report radiological–pathological correlation in human M. Computed tomography (CT) findings of this pneumonia are bronchovascular thickening, centrilobular nodules, ground-glass attenuation, or air-space consolidation ( Tanaka et al., 1985 Tanaka N. pneumoniae pneumonia on chest radiography are non-specific segmental or lobar consolidation, bilateral diffuse reticular interstitial infiltrates ( Putman et al., 1975). pneumoniae pneumonia ( Koletsky and Weinstein, 1980 Rollins et al., 1986 Ito et al., 1995 Ebnother et al., 2001 Izumikawa et al., 2014). Bronchiolitis and alveolitis with dense mononuclear cells infiltration, epithelioid cell granulation tissue filling alveolar ducts, organizing alveolar exudates, and hyaline membranes are characteristic findings in fulminant M. Pathological descriptions of this pneumonia include marked plasma cell-rich lymphocytic infiltration in peribronchial and perivascular areas, with accumulations of macrophages, neutrophils, and lymphocytes in the alveolar spaces, foci of interstitial pneumonia, and hyperplasia of type II pneumocytes ( Golden, 1944 Forsyth and Chanock, 1966 Meyers and Hirschman, 1972 Chan et al., 1999). pneumoniae pneumonia are rarely obtained. Therefore pathological specimens of human M. An estimated 3–13% of infected persons with infection experience pneumonia, and the remains are manifested as upper respiratory tract infection. ![]() The majority of Mycoplasma (M) pneumoniae respiratory infection are self-limited. pneumoniae pneumonia may be altered by the level of host CMI. It was suggested the pathological features of M. From these findings, up-regulation of host CMI could change radiological pattern to centrilobular nodules predominant, on the other hand down-regulation of host CMI would change radiological pattern to ground-glass opacity and consolidation. Patients with centrilobular nodules predominant radiologic pattern have a high level of CMI, measuring by tuberculin skin test. pulmonis-infected mice model, pathologic patterns are strikingly different according to host cell-mediated immunity (CMI) levels treatment with interleukin-2 lead to marked cellular bronchitis in the small airways and treatment with prednisolone or cyclosporin-A lead to neutrophils and exudates in the alveolar lumen. (3) Neutrophils and exudates in the alveolar lumen radiologically demonstrated as air-space consolidation or ground-glass opacities. (2) Cellular bronchitis in the small airways accompanied with exudates or granulation tissue in the lumen revealed as centrilobular nodules on CT. ![]() (1) Peribronchial and perivascular cuffing characterized by mononuclear cells infiltration was correlated with bronchovascular bundles thickening on CT, which was the most common finding of this pneumonia. Major three correlations were summarized. Therefore, we extensively reviewed the literature regarding pathological and radiological studies of Mycoplasma pneumonia, and compared findings between open lung biopsy specimen and computed tomography (CT). Studies focused on the pathological–radiological correlation of human Mycoplasma ( M) pneumoniae pneumonia have rarely been reported. NPO Sapporo Cough, Asthma, and Allergy Center, Sapporo, Japan.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |