The ET is a biomechanical valve between the nasopharynx and the middle ear. In an epidemiologically relevant disease with 2 million patients in the US every year, further research into its pathogenesis is important. Inadequate function of the Eustachian tube (ET) causes middle ear ventilation disorders. All other authors have declared that no competing interests exist. This does not alter our adherence to PLOS ONE policies on sharing data and materials. HörSys GmbH has no product or service that is part of this study and publication.Ĭompeting interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: SJ is employed by HörSys GmbH. HörSys GmbH only paid the salary of its own employees coauthoring this paper. HörSys GmbH is also a beneficiary of the joint-research grant “BMBF RESPONSE – partnership for innovation in implant technology, FKZ: 03ZZ0928C.” No money was transferred from HörSys GmbH to the authors of the other institutions. The specific roles of these authors are articulated in the ‘author contributions’ section. The funders provided support in the form of salaries for authors, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Data are available under the terms of the Creative Commons Zero “No rights reserved“ data waiver (CCO 1.0 Public domain dedication).įunding: This study was supported by BMBF RESPONSE – partnership for innovation in implant technology, FKZ 03ZZ0902E (awarded to TL) and HörSys GmbH (SJ). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: Repository: Functional Aspects of the Eustachian Tube by Means of 3D-Modeling Files (1,7 GB) contain the raw data, primary image data including segmentations, mutually spatially reconstructed image data, and quantitative evaluations. Received: DecemAccepted: JPublished: August 12, 2021Ĭopyright: © 2021 Schuon et al. PLoS ONE 16(8):Įditor: Rafael da Costa Monsanto, Universidade Federal de Sao Paulo/Escola Paulista de Medicina (Unifesp/epm), BRAZIL It indicates a limited spiraling rotation of the cartilaginous tube over its length and relevant positional relationships of the tensor and levator veli palatine muscles.Ĭitation: Schuon R, Schwarzensteiner J, Paasche G, Lenarz T, John S (2021) Functional aspects of the Eustachian tube by means of 3D-modeling. The model shows the topographic relation of the individual components, such as the bone and cartilage, the muscles and connective tissue, as well as the lining epithelium with the lumen. It was then compared with the cone-beam computed tomography dataset of the complete embedded specimen taken before slicing. The 3-D model was generated by the coherent alignment of the sections. To better describe the ET, its functional anatomy, and the biomechanical valve mechanism and subsequent development of diagnostic and interventional tools, a three-dimensional model based on thin-layer histology was created from an ET in this study. The underlying mechanism of ET dysfunction remains poorly understood except for an apparent genesis such as a nasopharyngeal tumor or cleft palate. The extent of dysfunction of the Eustachian tube (ET) is relevant in understanding the pathogenesis of secondary otological diseases such as acute or chronic otitis media.
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